Description

Z-Tyr-Otbu H2O is a protected tyrosine derivative, specifically the tert-butyl ester of N-carbobenzyloxy-L-tyrosine hydrate. This compound is a crucial building block in the synthesis of peptides and other complex organic molecules, offering a strategic combination of protecting groups for the amino and carboxyl functionalities. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors. The product is essential for developing peptide-based drugs, diagnostic agents, and advanced biochemical research tools.

Application

• Pharmaceutical Intermediates: A key raw material in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Peptide Synthesis: Serves as a protected amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS).
• Biochemical Research: Used in academic and industrial R&D for studying protein structure-function relationships and enzyme-substrate interactions.
• Proteomics & Diagnostics: Employed in the development of labeled peptides, antigens, and probes for diagnostic assays and proteomic studies.
• Combinatorial Chemistry: A valuable reagent in the generation of diverse chemical libraries for drug discovery and screening.

Basic Information

Product Name	Z-Tyr-Otbu H2O
CAS No.	16881-33-7
Molecular Formula	C₂₁H₂₅NO₆ • xH₂O
Molecular Weight	387.43 g/mol (anhydrous basis)
Synonyms	N-Carbobenzyloxy-L-tyrosine tert-butyl ester hydrate; Z-L-Tyrosine OtBu hydrate; Z-Tyr(tBu)-OH hydrate; (2S)-3-(4-Hydroxyphenyl)-2-[[(phenylmethoxy)carbonyl]amino]propanoic acid 1,1-dimethylethyl ester hydrate; Boc-Tyr-OtBu (common misnomer); CBZ-Tyrosine-OtBu hydrate; Nα-Z-L-Tyrosine tert-Butyl Ester Hydrate
EINECS	Contact for details

Quality Control

Our Z-Tyr-Otbu H2O is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, optical rotation, and water content (KF) determination, to ensure it meets the high standards required for pharmaceutical research and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-10.0° to -12.0° (c=1 in DMF)
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.