Description

Z-Lys(Tos)-Onp is a specialized amino acid derivative used as a key building block in peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates to ensure the fidelity and yield of complex peptide sequences. It is primarily utilized in pharmaceutical R&D and production for developing therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected lysine derivative for the controlled incorporation of lysine residues into peptide chains.
• Solution-Phase Peptide Synthesis: Used as an intermediate in classical solution-phase methods for constructing specific peptide fragments.
• Pharmaceutical Intermediate: A crucial precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: The reactive Onp (o-Nitrophenyl) ester group enables efficient coupling to other molecules, useful in creating labeled peptides or peptide-protein conjugates.
• Biochemical Research: Employed in academic and industrial laboratories for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Production of Custom Peptides: Essential for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide synthesis services.

Basic Information

Product Name	Z-Lys(Tos)-Onp
CAS No.	16879-94-0
Molecular Formula	C27H29N3O8S
Molecular Weight	555.60 g/mol
Synonyms	Z-Lys(Tos)-ONp; Nα-Carbobenzyloxy-Nε-tosyl-L-lysine o-Nitrophenyl Ester; Nα-Cbz-Nε-Tosyl-L-lysine 4-Nitrophenyl Ester; Cbz-Lys(Tos)-ONp; Z-Lys(Tos)-ONp ester; (S)-2-(((Benzyloxy)carbonyl)amino)-6-((4-methylphenyl)sulfonamido)hexanoic acid 4-nitrophenyl ester; Benzyl N-[(2S)-6-[(4-methylphenyl)sulfonylamino]-1-[(4-nitrophenoxy)-oxo]hexan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Z-Lys(Tos)-Onp is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, chiral purity, and impurity profiles. We adhere to cGMP standards where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.