Description

Z-Tyr(Tbu)-Onb is a protected tyrosine derivative widely used as a key synthetic intermediate in peptide chemistry. This compound is essential for researchers and manufacturers requiring high-purity building blocks to construct complex peptides and peptidomimetics with precise stereochemistry. It is primarily utilized in the pharmaceutical, biotechnology, and advanced materials research sectors for drug discovery and development projects.

Application

• Peptide Synthesis: A crucial protected amino acid building block for solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Serves as a key precursor in the synthesis of therapeutic peptides and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used in the preparation of peptide-protein conjugates, antibody-drug conjugates (ADCs), and other bioconjugates.
• Research & Development: Fundamental reagent in academic and industrial R&D for exploring new peptide-based drugs and biomaterials.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening.
• Proteomics & Biochemistry: Useful in the study of protein structure, function, and protein-protein interactions.

Basic Information

Product Name	Z-Tyr(Tbu)-Onb
CAS No.	16879-89-3
Molecular Formula	C22H27NO6
Molecular Weight	401.46 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-O-(tert-butyl)-L-tyrosine N-Hydroxysuccinimide Ester; Z-O-t-Butyl-L-tyrosine N-Hydroxysuccinimide Ester; Z-Tyr(OtBu)-OSu; Z-L-Tyrosine(O-t-butyl) N-succinimidyl ester; N-Cbz-O-tert-butyl-L-tyrosine N-hydroxysuccinimide ester; Z-Tyr(OtBu)-OSu Ester; NSC 334382; Benzyl N-[1-[[(2,5-dioxopyrrolidin-1-yl)oxy]-carbonyl]-2-[4-(tert-butoxy)phenyl]ethyl]carbamate
EINECS	Contact for details

Quality Control

Our Z-Tyr(Tbu)-Onb is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.