Description

Z-Thr-Onb (CAS NO 16879-84-8) is a protected amino acid derivative widely used as a crucial building block in peptide synthesis. Its primary value lies in providing a stable, orthogonal protecting group strategy for the threonine side chain, enabling complex multi-step synthetic sequences. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of threonine residues.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and small proteins in solution.
• Pharmaceutical Research: Serves as a building block for the development of peptide drugs, hormones, and enzyme inhibitors.
• Combinatorial Chemistry: Employed in libraries for drug discovery and structure-activity relationship (SAR) studies.
• Bioconjugation: Can be used to create peptide tags or linkers for protein labeling and bioconjugate chemistry.
• Academic & Industrial R&D: Fundamental reagent for synthetic chemistry research focused on amino acid and peptide chemistry.

Basic Information

Product Name	Z-Thr-Onb
CAS No.	16879-84-8
Molecular Formula	C₁₅H₂₀N₂O₆
Molecular Weight	324.33 g/mol
Synonyms	Z-Thr-ONb; N-Cbz-L-threonine p-nitrobenzyl ester; Nα-Carbobenzoxy-L-threonine 4-nitrobenzyl ester; Nα-Z-L-Threonine p-nitrobenzyl ester; Benzyloxycarbonyl-L-threonine 4-nitrobenzyl ester; (2S,3R)-2-[[(Benzyloxy)carbonyl]amino]-3-hydroxybutanoic acid 4-nitrobenzyl ester; L-Threonine, N-[(phenylmethoxy)carbonyl]-, 4-nitrobenzyl ester
EINECS	Contact for details

Quality Control

Every batch of Z-Thr-Onb is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high chemical and chiral purity, with specifications typically meeting or exceeding standards for advanced synthetic intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (by HPLC), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.