Description

L-Glutamic Acid Di-tert-Butylester Dibenzenesulfimide Salt is a protected derivative of the amino acid L-glutamic acid, specifically designed for advanced peptide synthesis and pharmaceutical research. This compound is crucial for enabling complex chemical transformations while preserving the stereochemical integrity of the glutamic acid side chain. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the production of novel peptides and peptidomimetics.

Application

• Peptide Synthesis: Serves as a key protected building block (Fmoc or Boc strategies) for the solid-phase and solution-phase synthesis of complex peptides.
• Pharmaceutical Intermediates: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways.
• Bioconjugation: Acts as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Prodrug Development: Employed in the design of prodrugs where the tert-butyl ester groups provide controlled release properties.
• Chemical Biology Research: A valuable tool for studying enzyme mechanisms, receptor-ligand interactions, and protein structure-function relationships.
• Fine Chemical Synthesis: Used as a chiral synthon in the asymmetric synthesis of non-peptide molecules with biological activity.

Basic Information

Item	Details
Product Name	L-Glutamic Acid Di-tert-Butylester Dibenzenesulfimide Salt
CAS No.	16874-06-9
Molecular Formula	C25H34N2O8S2
Molecular Weight	554.67 g/mol
Synonyms	H-Glu(OtBu)2-OH·Dbs; L-Glutamic acid α,γ-di-tert-butyl ester Dbs salt; Di-tert-butyl L-glutamate Dbs salt; Dibenzenesulfimide salt of L-glutamic acid di-tert-butyl ester; N-(tert-Butoxycarbonyl)-L-glutamic acid 1,5-di-tert-butyl ester Dbs salt (common misassignment); Fmoc-Glu(OtBu)-OH·Dbs (common protected form); Boc-Glu(OtBu)-OH·Dbs (common protected form)
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid Di-tert-Butylester Dibenzenesulfimide Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research and cGMP applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98.5%), and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation	[α]²⁰D = Specific range provided on COA
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.