Description

Z-His-NH2 CAS NO 16706-41-5 is a protected derivative of the amino acid L-histidine, featuring a benzyloxycarbonyl (Z) group at the N-terminus and an amidated C-terminus. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), offering enhanced stability and controlled reactivity during the formation of peptide bonds. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental N-protected amino acid building block for the controlled assembly of complex peptide sequences.
• Pharmaceutical Research: Used in the development and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Serves as a key intermediate for creating peptide-protein conjugates, antibody-drug conjugates (ADCs), and other labeled biomolecules.
• Biochemical Research: Employed in enzymatic studies, substrate synthesis, and the investigation of histidine's role in protein structure and function.
• Combinatorial Chemistry: Utilized in libraries for high-throughput screening to discover new bioactive compounds.
• Fine Chemical Synthesis: Acts as a chiral synthon for the asymmetric synthesis of more complex organic molecules.

Basic Information

Product Name	Z-His-NH2
CAS No.	16706-41-5
Molecular Formula	C14H18N4O3
Molecular Weight	290.32 g/mol
Synonyms	Nα-Carbobenzoxy-L-histidinamide; Nα-Cbz-L-histidinamide; Z-L-Histidine amide; Cbz-His-NH2; N-Carbobenzyloxy-L-histidinamide; Benzyl N-[(2S)-2-amino-1-(carbamoylamino)ethyl]carbamate; (S)-2-((((Benzyloxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanamide
EINECS	Contact for details

Quality Control

Our Z-His-NH2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.