Description

Alanine,3-(Trimethylsilyl)- is a specialized organosilicon derivative of the amino acid alanine, characterized by the introduction of a trimethylsilyl protecting group. This modification is critical for its primary role as a key synthetic intermediate and protecting group reagent in advanced organic synthesis, particularly in peptide chemistry. It is an essential material for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over molecular structure during multi-step syntheses.

Application

• Peptide Synthesis Intermediate: Serves as a crucial building block for the incorporation of modified alanine residues into peptide chains, enabling the study of structure-activity relationships.
• Amino Acid Protecting Group Reagent: The trimethylsilyl group protects reactive functional groups (like carboxyl or amino) during complex synthetic sequences, preventing unwanted side reactions.
• Pharmaceutical Research & Development: Used in the synthesis of novel drug candidates, prodrugs, and bioactive molecules where silicon-containing amino acid analogs are investigated.
• Agrochemical Active Ingredient Synthesis: Employed in the development of new pesticides and herbicides that may utilize silicon-modified amino acid frameworks.
• Organosilicon Chemistry Research: A valuable compound for academic and industrial research into the properties and applications of silylated biomolecules.
• Chiral Auxiliary or Ligand Precursor: Can be utilized in the development of chiral catalysts or auxiliaries for asymmetric synthesis due to its inherent chirality.

Basic Information

Product Name	Alanine,3-(Trimethylsilyl)-
CAS No.	16655-72-4
Molecular Formula	C6H15NO2Si
Molecular Weight	161.28 g/mol
Synonyms	3-(Trimethylsilyl)alanine; (2S)-2-Amino-3-(trimethylsilyl)propanoic acid; L-3-(Trimethylsilyl)alanine; Alanine, 3-(trimethylsilyl)-, L-; NSC 163063; Trimethylsilylalanine; Silylated alanine; TMS-Alanine
EINECS	Contact for details

Quality Control

Our Alanine,3-(Trimethylsilyl)- is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. While typically offered in research and technical grades, specifications including assay (by HPLC or titration), chiral purity, and identification (by IR/NMR) are rigorously controlled. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.