Description

L-Isoleucine Benzyl Ester 4-Toluenesulphonate is a protected amino acid derivative, specifically the benzyl ester salt of L-isoleucine with p-toluenesulfonic acid. This compound is a crucial chiral building block in organic synthesis, valued for its role in introducing the L-isoleucine moiety while protecting the carboxylic acid functionality. It is primarily needed by research institutions and pharmaceutical companies engaged in the development and production of peptides, peptidomimetics, and other bioactive molecules.

Application

• Peptide Synthesis: A key intermediate in solid-phase and solution-phase peptide synthesis for constructing peptide chains containing L-isoleucine.
• Pharmaceutical Intermediates: Serves as a critical chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Used in proteomics and enzymology research to study protein structure, function, and enzyme-substrate interactions.
• Prodrug Development: Utilized in the design and synthesis of prodrugs where the benzyl ester group can be cleaved enzymatically in vivo.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective organic reactions.
• Fine Chemical Manufacturing: An important building block for the production of complex, high-value specialty chemicals.

Basic Information

Product Name	L-Isoleucine Benzyl Ester 4-Toluenesulphonate
CAS No.	16652-75-8
Molecular Formula	C23H31NO5S
Molecular Weight	433.56 g/mol
Synonyms	L-Isoleucine benzyl ester tosylate; (2S,3S)-2-Amino-3-methylpentanoic acid benzyl ester 4-methylbenzenesulfonate; Benzyl L-isoleucinate 4-methylbenzenesulfonate; Isoleucine benzyl ester p-toluenesulfonate; H-Ile-OBzl·TosOH; L-Ile-OBzl Tosylate; L-Isoleucine benzyl ester p-toluenesulfonic acid salt
EINECS	Contact for details

Quality Control

Our L-Isoleucine Benzyl Ester 4-Toluenesulphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles. Our quality commitment aligns with the standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.