Description

L-Proline Benzyl Ester Hydrochloride is a protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block, enabling the controlled introduction of the proline residue while preventing unwanted side reactions. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and fine chemical manufacturers developing therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of proline into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for constructing complex peptide sequences.
• Pharmaceutical Intermediate: Serves as a precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies of protein structure, enzyme inhibitors, and receptor ligands.
• Production of Protected Amino Acids: Used to create specialized proline derivatives for custom synthesis projects.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse arrays of compounds for drug discovery screening.

Basic Information

Product Name	L-Proline Benzyl Ester Hydrochloride
CAS No.	16652-71-4
Molecular Formula	C₁₂H₁₅NO₂·HCl
Molecular Weight	241.71 g/mol (Free base: 205.25 g/mol)
Synonyms	L-Proline Benzyl Ester HCl; (S)-(-)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic Acid Hydrochloride; H-Pro-OBzl·HCl; Proline Benzyl Ester Hydrochloride; Benzyl L-prolinate hydrochloride; Pro-OBzl·HCl; Pyrrolidine-2-carboxylic acid benzyl ester hydrochloride; (S)-Pyrrolidine-2-carboxylic acid benzyl ester hydrochloride
EINECS	240-704-4

Quality Control

Our L-Proline Benzyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.