Description

Z-Trp-Onp is a protected amino acid derivative, specifically the N-benzyloxycarbonyl (Z) protected form of tryptophan with an o-nitrophenyl (Onp) ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient formation of peptide bonds. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the production of complex peptides, peptide hormones, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as an activated ester for the controlled incorporation of tryptophan residues into peptide chains.
• Pharmaceutical Intermediates: Key raw material in the synthesis of therapeutic peptides and peptide-based drugs.
• Biochemical Research: Used in academic and industrial R&D for studying peptide structure, function, and for developing novel bioactive compounds.
• Combinatorial Chemistry: A valuable reagent in the generation of peptide libraries for drug discovery and screening applications.
• Custom Peptide Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of custom peptides at various scales.
• Protecting Group Chemistry: Serves as a model compound in studies involving the Z (Cbz) protecting group and active ester methodologies.

Basic Information

Product Name	Z-Trp-Onp
CAS No.	16624-64-9
Molecular Formula	C27H25N3O6
Molecular Weight	487.51 g/mol
Synonyms	N-Carbobenzyloxy-L-tryptophan o-nitrophenyl ester; Z-L-Tryptophan 4-nitrophenyl ester; Cbz-L-Tryptophan ONP ester; Nα-Cbz-L-Tryptophan 4-nitrophenyl ester; N-Cbz-L-Tryptophan p-nitrophenyl ester; (S)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid 4-nitrophenyl ester; Benzyl N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(4-nitrophenoxy)propan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Z-Trp-Onp CAS NO 16624-64-9 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.