Description

L-Pyroglutamamide is a high-purity chiral building block and intermediate of significant interest in advanced organic synthesis. Its unique pyrrolidone-amide structure makes it a valuable precursor for the development of pharmaceuticals, bioactive peptides, and fine chemicals. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate the pyroglutamic acid moiety into complex molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly those targeting neurological and metabolic disorders.
• Peptide Chemistry: Used as a building block for the preparation of modified peptides and peptidomimetics with enhanced stability or biological activity.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and plant growth regulators.
• Biochemical Research: Employed in enzymatic studies and as a standard or reagent in analytical methodologies.
• Cosmetic Ingredient Synthesis: Intermediate for producing moisturizing and skin-conditioning agents derived from amino acids.
• Asymmetric Synthesis: A valuable starting material for catalysts or ligands used in stereoselective chemical transformations.

Basic Information

Product Name	L-Pyroglutamamide
CAS No.	16395-57-6
Molecular Formula	C5H8N2O2
Molecular Weight	128.13 g/mol
Synonyms	(S)-2-Oxopyrrolidine-1-carboxamide; L-2-Pyrrolidone-5-carboxamide; (S)-5-Carbamoylpyrrolidin-2-one; L-Pyroglutamic acid amide; PCA amide; L-Pyroglutamine; 5-Oxo-L-prolinamide; 1-Aminocarbonyl-5-oxo-L-proline
EINECS	Contact for details

Quality Control

Our L-Pyroglutamamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.