Description

21-Acetyloxy-9-Fluoro-11-(Trifluoroace-Tyloxy)-17-Hydroxy-16-Methylpregna-1,4-Diene-3,20-Dione CAS NO 16394-70-0 is a high-purity synthetic steroid derivative, specifically a fluorinated and acylated pregnadiene. This compound is a critical advanced pharmaceutical intermediate valued for its precise molecular structure, which serves as a key building block in the synthesis of potent corticosteroid APIs. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development and production of novel anti-inflammatory and immunosuppressive therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of high-potency topical and systemic corticosteroid drugs.
• Steroid Research & Development: Used in academic and industrial laboratories for investigating structure-activity relationships (SAR) of fluorinated steroids.
• Active Pharmaceutical Ingredient (API) Synthesis: Integral in the manufacturing process chain for specific, potent glucocorticoid receptor agonists.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of steroid-based medicines.
• Biochemical Studies: Utilized in vitro studies to understand steroid metabolism and receptor binding mechanisms.

Basic Information

Item	Detail
Product Name	21-Acetyloxy-9-Fluoro-11-(Trifluoroace-Tyloxy)-17-Hydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
CAS No.	16394-70-0
Molecular Formula	C₂₈H₃₂F₄O₇
Molecular Weight	556.55 g/mol
Synonyms	9α-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate 11-trifluoroacetate; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione cyclic 11,21-bis(trifluoroacetate); Diflucortolone Valerate Intermediate; Diflucortolone related compound; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate 11-trifluoroacetate; NSC 121773; Fluocortolone Impurity
EINECS	Contact for details

Quality Control

Our 21-Acetyloxy-9-Fluoro-11-(Trifluoroace-Tyloxy)-17-Hydroxy-16-Methylpregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and impurity profiling, to ensure it meets exacting standards for pharmaceutical intermediate use. Certificates of Analysis (COA) with full traceability are provided, confirming identity, purity, and compliance with in-house specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.