Description

n-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline is a specialized heterocyclic building block and a derivative of the EEDQ reagent, primarily used as a versatile coupling agent and protecting group in organic synthesis. Its value lies in facilitating peptide bond formation and other condensation reactions under mild conditions, offering advantages in yield and selectivity. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors developing novel active compounds.

Application

• Peptide Synthesis: Employed as a coupling reagent for the formation of amide (peptide) bonds, particularly useful in solid-phase and solution-phase synthesis of complex peptides and proteins.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of various drug candidates, including those with quinoline-based structures for therapeutic applications.
• Agrochemical Development: Used in the research and production of advanced pesticides and herbicides where specific heterocyclic frameworks are required.
• Material Science: Acts as a precursor or modifying agent in the creation of specialty polymers and functional organic materials.
• Bioconjugation: Facilitates the linking of biomolecules (e.g., proteins, antibodies) with other molecules for diagnostic and therapeutic purposes.
• Academic & Industrial R&D: A valuable tool for chemists in exploratory research for developing new synthetic methodologies and novel chemical entities.

Basic Information

Product Name	n-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
CAS No.	16357-59-8
Molecular Formula	C₁₄H₁₇NO₃
Molecular Weight	247.29 g/mol
Synonyms	EEDQ; N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline; 1,2-Dihydro-2-ethoxy-1-ethoxycarbonylquinoline; Ethyl 2-ethoxy-1,2-dihydro-1-quinolinecarboxylate; N-(Ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline; Quinoline, 1,2-dihydro-2-ethoxy-1-ethoxycarbonyl-; Coupling Agent EEDQ
EINECS	Contact for details

Quality Control

Our n-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.