Description

H-Gly-Onp Hcl CAS NO 16336-29-1 is a high-purity, protected amino acid derivative widely used as a critical building block in peptide synthesis and pharmaceutical research. Its primary value lies in providing a precisely controlled reactive site for constructing complex peptide chains, enabling the development of novel therapeutic agents and biochemical tools. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for advanced organic synthesis.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected glycine derivative for the sequential assembly of peptides on resin supports.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Bioconjugation: Used to introduce glycine linkers or spacers in the modification of proteins, antibodies, and other biomolecules.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for drug discovery and screening applications.
• Research & Development: A fundamental reagent in academic and industrial R&D labs for studying peptide structure, function, and metabolism.
• Fine Chemical Synthesis: Utilized in the custom synthesis of complex organic molecules requiring protected amino acid motifs.

Basic Information

Product Name	H-Gly-Onp Hcl
CAS No.	16336-29-1
Molecular Formula	C9H11ClN2O3
Molecular Weight	230.65 g/mol
Synonyms	Glycine, N-[(4-nitrophenoxy)carbonyl]-, hydrochloride; N-[(4-Nitrophenoxy)carbonyl]glycine hydrochloride; N-Carboxyglycine 4-nitrophenyl ester hydrochloride; H-Gly-ONp·HCl; 4-Nitrophenyloxycarbonyl-glycine hydrochloride; Glycine, N-[(4-nitrophenoxy)carbonyl]-, hydrochloride (1:1); Z-Gly-ONp (common abbreviation, though technically for Cbz); ONp-Gly-OH·HCl
EINECS	Contact for details

Quality Control

Our H-Gly-Onp Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.