Description

(2S,4R)-4-Bromopyrrolidine-2-Carboxylic Acid CAS NO 16257-71-9 is a high-purity, non-natural chiral amino acid derivative featuring a brominated pyrrolidine scaffold. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, offering precise stereochemical control. It is primarily required by pharmaceutical R&D and fine chemical synthesis laboratories for applications in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, such as HCV NS3/4A protease inhibitors, and other therapeutic agents.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints and enhance metabolic stability in peptide-based drug candidates.
• Organocatalyst & Ligand Synthesis: Serves as a precursor for chiral catalysts and ligands used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tools for studying enzyme function.
• Agrochemical Research: Utilized as a building block in the discovery of novel, chiral active ingredients with specific biological activity.
• Academic & Contract Research: Essential for medicinal chemistry programs and methodological studies in academic and CRO settings.

Basic Information

Product Name	(2S,4R)-4-Bromopyrrolidine-2-Carboxylic Acid
CAS No.	16257-71-9
Molecular Formula	C5H8BrNO2
Molecular Weight	194.03 g/mol
Synonyms	(2S,4R)-4-Bromo-2-pyrrolidinecarboxylic acid; (4R)-4-Bromo-L-proline; 4-Bromo-L-proline; 4-Bromoproline; L-4-Bromoproline; (2S,4R)-4-Bromoproline; 4-Bromo-(S)-proline; 16257-71-9
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-Bromopyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.