Description

Hexafluoroleucine is a fluorinated derivative of the essential amino acid leucine, characterized by the strategic replacement of hydrogen atoms with fluorine. This high-value synthetic building block is crucial for advanced research and development, particularly in modulating the biological activity, metabolic stability, and physicochemical properties of peptides and other bioactive compounds. It is primarily utilized by pharmaceutical researchers, agrochemical developers, and specialized material scientists working on cutting-edge applications.

Application

• Pharmaceutical Research & Development: A key fluorinated building block for the synthesis of novel peptide-based therapeutics, enzyme inhibitors, and PET (Positron Emission Tomography) tracers, where fluorine atoms enhance metabolic stability and membrane permeability.
• Agrochemical Innovation: Used in the design and synthesis of new-generation herbicides, pesticides, and plant growth regulators, leveraging fluorine's ability to improve lipophilicity and biological activity.
• Peptide Engineering & Medicinal Chemistry: Incorporated into peptide sequences to study structure-activity relationships (SAR), improve proteolytic resistance, and create analogs with tailored pharmacological profiles.
• Biochemical & Metabolic Studies: Serves as a stable isotopic or fluorinated probe in metabolic pathway analysis and mechanistic studies of amino acid processing.
• Material Science Precursor: Acts as a specialized monomer or intermediate for developing fluorinated polymers, coatings, or surfaces with unique hydrophobic and oleophobic properties.

Basic Information

Product Name	Hexafluoroleucine
CAS No.	16198-60-0
Molecular Formula	C6H6F6NO2
Molecular Weight	238.11 g/mol
Synonyms	L-Hexafluoroleucine; (2S)-2-Amino-4,4,5,5,5,5-hexafluoropentanoic acid; 4,4,5,5,5,5-Hexafluoroleucine; 2-Amino-4,4,5,5,5,5-hexafluoropentanoic acid; F6-Leu; Hexafluoro-leucine; 4,4,5,5,5,5-Hexafluoro-L-leucine
EINECS	Contact for details

Quality Control

Our Hexafluoroleucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (L-Isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.