Description

Boc-D-Phenylalanine 4-Nitrophenyl Ester is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a crucial building block, enabling the controlled and stereospecific incorporation of D-phenylalanine into peptide chains. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and chiral catalysts.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key activated ester intermediate for the efficient coupling of D-Phenylalanine in automated peptide synthesizers.
• Solution-Phase Peptide Chemistry: Used in the synthesis of complex, biologically active peptides and peptide libraries for drug discovery.
• Pharmaceutical Intermediates: Serves as a critical precursor in the manufacturing of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Facilitates the site-specific labeling of peptides with probes, tags, or other molecules for diagnostic and research applications.
• Asymmetric Synthesis: Employed as a chiral auxiliary or reagent in the synthesis of non-peptidic compounds requiring high enantiomeric purity.
• Academic & Industrial R&D: A fundamental reagent for exploring new synthetic methodologies and studying peptide structure-activity relationships.

Basic Information

Product Name	Boc-D-Phenylalanine 4-Nitrophenyl Ester
CAS No.	16159-70-9
Molecular Formula	C20H22N2O6
Molecular Weight	386.40 g/mol
Synonyms	Boc-D-Phe-ONp; (R)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropanoic acid 4-nitrophenyl ester; tert-Butyloxycarbonyl-D-phenylalanine p-nitrophenyl ester; N-(tert-Butoxycarbonyl)-D-phenylalanine 4-nitrophenyl ester; Boc-D-Phenylalanine p-nitrophenyl ester; N-Boc-D-phenylalanine 4-nitrophenyl ester; Boc-D-Phe-ONp ester; D-Boc-Phenylalanine p-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Boc-D-Phenylalanine 4-Nitrophenyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation (IR, NMR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.