Description

Cromolyn Sodium Related Compound A (25 Mg) (1,3-Bis-(2-Acetyl-3-Hydroxyphenoxy)-2-Propanol) (As) is a high-purity analytical reference standard and a key chemical intermediate. This compound is critical for pharmaceutical research and development, particularly in the synthesis and quality control of cromolyn sodium, a well-known mast cell stabilizer. It serves as an essential tool for analytical chemists and process development scientists in the pharmaceutical and fine chemical industries, ensuring the accuracy and reliability of chromatographic and spectroscopic methods.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the identification, assay, and impurity profiling of cromolyn sodium in accordance with pharmacopeial methods (USP, EP).
• Analytical Method Development & Validation: Critical for developing and validating HPLC, UPLC, and GC methods to ensure specificity, accuracy, and precision in quality control laboratories.
• Process Chemistry & Impurity Synthesis: Used as a building block or a marker in the synthesis of cromolyn sodium and for the preparation of related impurities to support regulatory filings (e.g., ICH guidelines).
• Stability Studies: Employed as a known degradation product or impurity to monitor the stability and shelf-life of cromolyn sodium drug substances and finished products.
• Academic & Contract Research: Serves as a research chemical in universities and CROs for studying the pharmacology, metabolism, and structure-activity relationships of chromone derivatives.

Basic Information

Product Name	Cromolyn Sodium Related Compound A (25 Mg) (1,3-Bis-(2-Acetyl-3-Hydroxyphenoxy)-2-Propanol) (As)
CAS No.	16150-44-0
Molecular Formula	C22H22O8
Molecular Weight	414.41 g/mol
Synonyms	1,3-Bis(2-acetyl-3-hydroxyphenoxy)-2-propanol; Cromolyn Impurity A; Cromoglicic Acid Related Compound A; Disodium Cromoglycate Related Compound A; 2-Propanol, 1,3-bis(2-acetyl-3-hydroxyphenoxy)-; Cromolyn Sodium Impurity A; 1,3-Bis-(2-Acetyl-3-Hydroxyphenoxy)propan-2-ol; FPL-670 Related Compound
EINECS	Contact for details

Quality Control

Every batch of Cromolyn Sodium Related Compound A is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure compliance with industry standards for reference materials. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.