Description

Acetaminophen Glucuronide is a primary, water-soluble metabolite of the common analgesic and antipyretic drug acetaminophen (paracetamol). This compound is of significant value in pharmaceutical research and development, serving as a critical reference standard and biomarker. It is essential for scientists and quality control professionals in the pharmaceutical, biotechnology, and clinical diagnostics industries who require high-purity metabolites for pharmacokinetic studies, drug metabolism research, and analytical method validation.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification of acetaminophen metabolites in biological matrices during drug development and bioequivalence studies.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic pathways, pharmacokinetics, and detoxification mechanisms of acetaminophen.
• Clinical Diagnostics: Employed in calibrating assays for therapeutic drug monitoring (TDM) and for assessing liver function and potential acetaminophen toxicity in patient samples.
• Analytical Method Development: Serves as a key standard for developing and validating High-Performance Liquid Chromatography (HPLC), LC-MS/MS, and other analytical techniques in bioanalytical laboratories.
• Toxicology Studies: Used to study the correlation between metabolite levels and hepatotoxicity, aiding in safety profiling.
• Enzyme Activity Assays: Applied in research to study the activity of UDP-glucuronosyltransferase (UGT) enzymes responsible for its formation.

Basic Information

Product Name	Acetaminophen Glucuronide
CAS No.	16110-10-4
Molecular Formula	C₁₇H₂₁NO₉
Molecular Weight	383.35 g/mol
Synonyms	Paracetamol Glucuronide; APAP Glucuronide; 4'-Hydroxyacetanilide Glucuronide; N-Acetyl-p-aminophenyl-β-D-glucopyranosiduronic Acid; 1-O-(4-Acetamidophenyl)-β-D-glucopyranuronic Acid; Acetaminophen β-D-Glucuronide; (Acetamidophenyl)glucuronide
EINECS	Contact for details

Quality Control

Our Acetaminophen Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for reference standard applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC is provided with every shipment to support your research and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.