Description

Hexafluoro-Dl-Valine CAS NO 16063-80-2 is a fluorinated derivative of the amino acid valine, characterized by the substitution of all six hydrogen atoms on its two methyl groups with fluorine atoms. This high degree of fluorination imparts unique properties, such as enhanced metabolic stability and lipophilicity, making it a critical building block in advanced chemical synthesis. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel peptides, proteolysis-targeting chimeras (PROTACs), and other bioactive compounds where fluorine substitution is strategically employed.

Application

• Pharmaceutical Intermediate: A key synthon for incorporating fluorinated valine residues into peptide-based drugs and bioactive molecules to modulate their stability, bioavailability, and binding affinity.
• PROTAC & Molecular Glue Development: Used in the synthesis of targeted protein degraders, where its fluorinated structure can enhance cellular permeability and pharmacokinetic properties.
• Agrochemical Research: Serves as a precursor in creating novel fluorinated pesticides and herbicides with potentially improved environmental persistence and efficacy.
• Material Science: Employed in the synthesis of fluorinated polymers and surface modifiers to alter material properties like hydrophobicity and chemical resistance.
• Biochemical & Isotope Labeling: Useful in metabolic studies and as a precursor for 18F or 19F labeling agents used in Positron Emission Tomography (PET) imaging and NMR spectroscopy.
• Academic & Contract Research: A valuable reagent for universities and CROs exploring the structure-activity relationships of fluorinated amino acids in various biological systems.

Basic Information

Product Name	Hexafluoro-Dl-Valine
CAS No.	16063-80-2
Molecular Formula	C5H5F6NO2
Molecular Weight	225.09 g/mol
Synonyms	DL-2-Amino-3-methyl-3,3,4,4,4-pentafluorobutyric acid; (RS)-2-Amino-3-methyl-3,3,4,4,4-pentafluorobutanoic acid; 3,3,4,4,4-Pentafluoro-DL-valine; Hexafluorovaline; Pentafluorovaline; F6Val; HfV; 2-Amino-3-methyl-3,3,4,4,4-pentafluorobutanoic acid
EINECS	Contact for details

Quality Control

Our Hexafluoro-Dl-Valine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to strong bases and fluorides; keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.