Description

2-(Trifluoromethyl)-4H-3,1-Benzoxazin-4-One is a high-purity, fluorinated heterocyclic compound serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the unique reactivity of the benzoxazinone core combined with the electron-withdrawing and lipophilicity-enhancing properties of the trifluoromethyl group. This makes it an indispensable building block for researchers and manufacturers developing novel active ingredients, particularly within the pharmaceutical and agrochemical sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group often enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or organic electronic materials requiring fluorinated aromatic components.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex heterocyclic frameworks via ring-opening or functional group transformation reactions.
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and agrochemistry.

Basic Information

Product Name	2-(Trifluoromethyl)-4H-3,1-Benzoxazin-4-One
CAS No.	16062-71-8
Molecular Formula	C9H4F3NO2
Molecular Weight	215.13 g/mol
Synonyms	2-(Trifluoromethyl)-4H-benzo[e][1,3]oxazin-4-one; 2-(Trifluoromethyl)-1,3-benzoxazin-4-one; 4H-3,1-Benzoxazin-4-one, 2-(trifluoromethyl)-; 2-Trifluoromethyl-4H-3,1-benzoxazin-4-one; 2-Trifluoromethylbenzoxazinone; 2-Trifluoromethyl-4H-benzo[d][1,3]oxazin-4-one; 2-(Trifluoromethyl)-4H-benzo[d][1,3]oxazin-4-one
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)-4H-3,1-Benzoxazin-4-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.