Description

Iotrizoic Acid CAS NO 16024-67-2 is a key iodinated organic compound primarily used as a crucial intermediate in the synthesis of X-ray contrast media. Its high iodine content and specific chemical structure make it essential for producing safe and effective diagnostic agents. This product is vital for pharmaceutical manufacturers and research institutions developing non-ionic, low-osmolar contrast media for enhanced patient safety during radiographic procedures.

Application

• Primary Intermediate for X-ray Contrast Media: The fundamental building block for synthesizing iopamidol, iohexol, and other non-ionic contrast agents.
• Pharmaceutical Research & Development: Used in the discovery and process development of new iodinated diagnostic compounds.
• Active Pharmaceutical Ingredient (API) Synthesis: A critical raw material in the multi-step manufacturing process of final contrast agent APIs.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Specialty Organic Synthesis: Employed in research for creating other complex molecules where a tri-iodinated benzene derivative is required.

Basic Information

Product Name	Iotrizoic Acid
CAS No.	16024-67-2
Molecular Formula	C11H9I3N2O4
Molecular Weight	613.92 g/mol
Synonyms	5-Acetamido-2,4,6-triiodo-N-methylisophthalamic Acid; 5-Acetamido-2,4,6-triiodo-N-methylisophthalamic acid; Iotroxic Acid Impurity; NSC 113945; 2,4,6-Triiodo-5-[(methylcarbamoyl)amino]-N-acetyl-isophthalamic Acid; Iotrizoic Acid (USP); Iotrozoic Acid; Ioxtrizoic Acid
EINECS	240-169-6

Quality Control

Our Iotrizoic Acid is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for pharmaceutical intermediate use, including identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing results from advanced analytical techniques like HPLC and NMR. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.