Description

Z-Ala-Ala-Oh is a protected dipeptide derivative, specifically the benzyloxycarbonyl (Z) protected form of alanyl-alanine. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS), where it is used to introduce the Ala-Ala sequence while the Z-group provides orthogonal protection for the N-terminus. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing novel peptides for therapeutic and diagnostic applications.

Application

• Peptide Synthesis Intermediate: A fundamental building block for the controlled elongation of peptide chains in both research and commercial-scale synthesis.
• Pharmaceutical Research: Used in the development and production of active pharmaceutical ingredients (APIs) for peptide-based drugs targeting metabolic, oncological, and infectious diseases.
• Bioconjugation & Probe Development: Serves as a spacer or linker component in the creation of labeled peptides for diagnostic assays and imaging studies.
• Enzyme Substrate Studies: Acts as a model substrate for studying the specificity and kinetics of proteolytic enzymes like elastase and other serine proteases.
• Academic & Industrial R&D: A key reagent in laboratories focused on medicinal chemistry, structural biology, and chemical biology for exploring protein-protein interactions.
• Custom Peptide Service Providers: A standard raw material for companies offering bespoke peptide manufacturing services to the global research community.

Basic Information

Product Name	Z-Ala-Ala-Oh
CAS No.	16012-70-7
Molecular Formula	C16H22N2O5
Molecular Weight	322.36 g/mol
Synonyms	N-Cbz-L-alanyl-L-alanine; N-Carbobenzoxy-L-alanyl-L-alanine; Z-L-Ala-L-Ala-OH; Benzyloxycarbonyl-L-alanyl-L-alanine; Cbz-Ala-Ala-OH; Nα-Cbz-L-alanyl-L-alanine; N-[(Benzyloxy)carbonyl]-L-alanyl-L-alanine; L-Alanine, N-[(phenylmethoxy)carbonyl]-, L-alanyl-
EINECS	240-165-3

Quality Control

Our Z-Ala-Ala-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Every lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	-20° to -25° (c=1 in Acetic Acid)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.