Description

2-Amino-4,4,4-Trifluorobutyric Acid is a high-value, non-proteinogenic amino acid derivative characterized by its trifluoromethyl group, which imparts unique physicochemical properties. This compound is a critical building block in medicinal chemistry, where its fluorine atoms are leveraged to enhance metabolic stability, lipophilicity, and bioavailability of target molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated drugs, including protease inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with improved environmental profiles.
• Peptide Modification: Incorporated into peptides to study structure-activity relationships and enhance peptide stability against enzymatic degradation.
• Ligand and Catalyst Development: Serves as a precursor for creating novel fluorinated ligands used in asymmetric catalysis.
• Biochemical Research: Employed as a tool compound in metabolic studies and enzyme inhibition assays.
• Material Science: Potential monomer for synthesizing specialty polymers with unique surface properties.

Basic Information

Product Name	2-Amino-4,4,4-Trifluorobutyric Acid
CAS No.	15960-05-1
Molecular Formula	C4H6F3NO2
Molecular Weight	157.09 g/mol
Synonyms	4,4,4-Trifluoro-DL-norvaline; DL-4,4,4-Trifluoronorvaline; 2-Amino-4,4,4-trifluorobutanoic Acid; (±)-2-Amino-4,4,4-trifluorobutyric Acid; 4,4,4-Trifluoronorvaline; NSC 334365; 4,4,4-Trifluoro-2-aminobutanoic Acid
EINECS	240-104-9

Quality Control

Our 2-Amino-4,4,4-Trifluorobutyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.