Description

2-Amino-4,4,4-Trifluoro-n-Butyric Acid Hydrochloride is a high-purity, non-natural amino acid derivative characterized by its trifluoromethyl group, which imparts unique physicochemical properties. This compound is a critical building block in pharmaceutical research and development, particularly for the synthesis of novel bioactive molecules and peptide mimetics. It is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorine for enhanced metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, enzyme modulators, and other small-molecule therapeutics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce fluorinated amino acid residues, altering peptide stability and membrane permeability.
• Agrochemical Research: Serves as a precursor in the synthesis of novel herbicides, pesticides, and plant growth regulators with improved efficacy.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and fluorinated tags for studying biological mechanisms.
• Material Science: A potential monomer or modifier for creating specialty polymers with specific surface properties or stability.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and cGMP manufacturing of Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	2-Amino-4,4,4-Trifluoro-n-Butyric Acid Hydrochloride
CAS No.	15959-93-0
Molecular Formula	C4H7F3NO2 • HCl
Molecular Weight	197.56 g/mol (Free base: 161.10 g/mol)
Synonyms	2-Amino-4,4,4-trifluorobutanoic acid hydrochloride; (R/S)-2-Amino-4,4,4-trifluorobutyric acid hydrochloride; 4,4,4-Trifluoro-DL-norvaline hydrochloride; DL-4,4,4-Trifluoronorvaline HCl; 2-Amino-4,4,4-trifluorobutanoic acid HCl salt; 4,4,4-Trifluoronorvaline hydrochloride; (±)-2-Amino-4,4,4-trifluorobutyric acid hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and manufacturing. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity where applicable. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. We support development from non-GMP research to cGMP production scales, with documentation tailored to your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed and under an inert atmosphere if opened, to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.