Description

Ac-Nva-Oh is a protected amino acid derivative, specifically the acetylated form of L-norvaline. This high-purity building block is critical for the synthesis of complex peptides and bioactive compounds where precise molecular structure and chiral integrity are paramount. It serves as a key intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors, enabling the development of novel therapeutics and specialized polymers.

Application

• Pharmaceutical Intermediate: A crucial building block in the solid-phase and solution-phase synthesis of peptide-based drugs and diagnostic agents.
• Bioconjugation & Linker Chemistry: Used in the design and synthesis of peptide-drug conjugates (PDCs) and antibody-drug conjugates (ADCs) due to its reactive carboxyl group.
• Proteomics Research: Employed in the study of enzyme substrates and inhibitors, as well as in the preparation of custom peptide libraries for high-throughput screening.
• Biomaterial Synthesis: Serves as a monomer or modifying agent in the creation of functionalized, biodegradable polymers for medical and industrial applications.
• Chemical Biology Tool: Utilized to introduce the norvaline moiety into proteins or peptides to study structure-activity relationships (SAR) and metabolic pathways.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Ac-Nva-Oh
CAS No.	15891-50-6
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	N-Acetyl-L-norvaline; Ac-L-Nva-OH; (S)-2-Acetamidopentanoic acid; L-2-Acetamidovaleric acid; N-Acetylnorvaline; Ac-Norvaline-OH; Norvaline, N-acetyl-, L-; NSC 334905
EINECS	Contact for details

Quality Control

Our Ac-Nva-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.