Description

6-Thioguanylic Acid is a modified nucleotide analog of guanosine monophosphate, where the oxygen atom at the 6-position is replaced by sulfur. This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a key intermediate and its unique biological activity. It is primarily utilized by researchers and manufacturers in the fields of nucleic acid chemistry, antiviral drug development, and molecular biology.

Application

• Biochemical Research: Used as a critical reagent and building block in the study of nucleic acid structure, function, and enzyme interactions.
• Pharmaceutical Intermediates: Serves as a key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Molecular Probes: Employed in the development of labeled nucleotides for diagnostic assays and sequencing technologies.
• Enzyme Studies: Acts as a substrate or inhibitor for various enzymes, including kinases and polymerases, to investigate metabolic pathways.
• Antisense Oligonucleotide Development: Incorporated into oligonucleotide sequences to modify their stability and binding properties for therapeutic applications.

Basic Information

Product Name	6-Thioguanylic Acid
CAS No.	15867-02-4
Molecular Formula	C10H14N5O7PS
Molecular Weight	379.28 g/mol
Synonyms	6-Thio-GMP; 6-Thioguanosine 5'-Monophosphate; 6-Thioguanosine Monophosphate; 6-Mercaptoguanosine 5'-Phosphate; Guanosine 5'-(dihydrogen phosphate), 6-thio-; 6-SH-GMP; 6-TGMP; NSC 177544
EINECS	Contact for details

Quality Control

Our 6-Thioguanylic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for moisture and related substances. We provide Certificates of Analysis (COA) with every shipment, detailing all test results to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.