Description

3B,11B,17Alpha,21-Tetrahydroxy-5B-Pregnan-20-One is a high-purity steroid intermediate, specifically a tetrahydroxylated pregnane derivative. This compound is valued for its role as a critical synthetic precursor in the production of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and synthesis of corticosteroids and other therapeutic steroids. The material's defined stereochemistry and functional groups make it essential for precise chemical transformations in advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid APIs, such as certain anti-inflammatory agents.
• Biochemical Research: Used as a reference standard or starting material in metabolic pathway studies and steroid hormone research.
• Process Development: Serves as a critical intermediate for process chemistry teams scaling up steroid manufacturing routes.
• Custom Synthesis: A foundational substrate for contract research organizations (CROs) and CDMOs producing specialized steroid analogs.

Basic Information

Product Name	3B,11B,17Alpha,21-Tetrahydroxy-5B-Pregnan-20-One
CAS No.	15734-50-6
Molecular Formula	C21H34O5
Molecular Weight	366.50 g/mol
Synonyms	5β-Pregnane-3β,11β,17α,21-tetrol-20-one; 3β,11β,17α,21-Tetrahydroxy-5β-pregnan-20-one; 20-Oxo-5β-pregnane-3β,11β,17α,21-tetrol; Tetrahydrocortisol (5β-isomer); 5β-Tetrahydrocortisol; 3β,11β,17α,21-Tetrahydroxy-5β-pregnane-20-one; Urocortisol; 5β-THF
EINECS	Contact for details

Quality Control

Our 3B,11B,17Alpha,21-Tetrahydroxy-5B-Pregnan-20-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral methods for stereochemical confirmation, and residual solvent analysis. We provide a Certificate of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.