Description

Methyl 3,3,3-Trifluoro-2-Phenylalaninate is a high-value fluorinated amino acid ester derivative, serving as a critical chiral building block in advanced organic synthesis. Its core value lies in the introduction of a trifluoromethyl group, which significantly alters the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and probing structure-activity relationships.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of fluorinated peptide mimetics, protease inhibitors, and other bioactive molecules.
• Agrochemical Research: Building block for novel herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and environmental persistence.
• Material Science: Precursor for specialty polymers and liquid crystals with unique optical and electronic properties.
• Medicinal Chemistry: Used in lead optimization to improve the pharmacokinetic profile and metabolic stability of drug candidates.
• Asymmetric Synthesis: Valuable substrate for catalytic reactions to study stereoselective transformations.
• Chemical Biology: Tool compound for incorporating fluorinated motifs into peptides and proteins to study biological interactions.

Basic Information

Product Name	Methyl 3,3,3-Trifluoro-2-Phenylalaninate
CAS No.	15467-28-4
Molecular Formula	C11H10F3NO2
Molecular Weight	245.20 g/mol
Synonyms	Methyl (2R)-3,3,3-trifluoro-2-phenylalaninate; Methyl (2S)-3,3,3-trifluoro-2-phenylalaninate; Methyl 2-amino-3,3,3-trifluoro-3-phenylpropanoate; 3,3,3-Trifluoro-2-phenylalanine methyl ester; (R)-Methyl 3,3,3-trifluoro-2-phenylalaninate; (S)-Methyl 3,3,3-trifluoro-2-phenylalaninate; Methyl α-amino-β,β,β-trifluorohydrocinnamate; NSC 334906
EINECS	Contact for details

Quality Control

Our Methyl 3,3,3-Trifluoro-2-Phenylalaninate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic confirmation (NMR, IR) are provided to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer-specific grades available)
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.