Description

Boc-Pro-Pro-Oh is a protected dipeptide building block, specifically N-(tert-Butoxycarbonyl)-L-prolyl-L-proline, widely utilized in solid-phase peptide synthesis (SPPS). This compound is essential for constructing complex peptide sequences, offering a strategic combination of a Boc-protected N-terminus and a free carboxylic acid for chain elongation. It is a critical raw material for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, peptidomimetics, and biochemical probes. Its defined stereochemistry and high purity are paramount for ensuring the fidelity and yield of the final peptide product.

Application

• Pharmaceutical Intermediates: A key building block in the synthesis of therapeutic peptides targeting various diseases.
• Biochemical Research: Used in academic and industrial R&D for studying protein-protein interactions and enzyme mechanisms.
• Peptidomimetic Development: Serves as a scaffold for creating stable, drug-like molecules that mimic natural peptides.
• Solid-Phase Peptide Synthesis (SPPS): Employed in automated and manual peptide synthesis for the controlled addition of proline residues.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of compounds for high-throughput screening.
• API (Active Pharmaceutical Ingredient) Manufacturing: Used in the commercial-scale production of peptide-based active ingredients.

Basic Information

Product Name	Boc-Pro-Pro-Oh
CAS No.	15401-08-8
Molecular Formula	C₁₅H₂₄N₂O₅
Molecular Weight	312.36 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-prolyl-L-proline; Boc-L-Pro-L-Pro-OH; (S)-2-((S)-1-((tert-Butoxycarbonyl)pyrrolidine-2-carboxamido)pyrrolidine-1-carboxylic acid; Boc-Pro-Pro; BOC-Pro-Pro-OH; tert-Butyloxycarbonyl-Pro-Pro-OH; N-Boc-L-prolyl-L-proline; Nα-Boc-L-prolyl-L-proline
EINECS	Contact for details

Quality Control

Our Boc-Pro-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via IR and NMR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material consistency suitable for demanding applications in pharmaceutical development and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-70° to -80° (c=1, in AcOH)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.