Description

2'-C-Methyladenosine is a chemically modified nucleoside analog of adenosine, distinguished by a methyl group at the 2'-carbon position of the ribose sugar. This structural modification is critical for its role as a key intermediate and building block in the research and development of antiviral and anticancer therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on nucleotide chemistry and drug discovery. The compound's significance lies in its ability to inhibit viral RNA replication, making it a valuable scaffold for probing biological mechanisms and developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of nucleoside-based antiviral and anticancer prodrugs.
• Antiviral Research: Used in biochemical studies targeting RNA-dependent RNA polymerases of viruses such as Hepatitis C Virus (HCV).
• Medicinal Chemistry: Acts as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of nucleotide analogs.
• Biochemical Tool: Employed as a substrate or inhibitor in enzymatic assays to study polymerase function and nucleotide metabolism.
• Preclinical Development: Utilized in the formulation and testing of potential therapeutic candidates in vitro and in vivo.
• Reference Standard: Functions as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2'-C-Methyladenosine
CAS No.	15397-12-3
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	2'-C-Methyladenosine; 2'-Methyladenosine; 2'-C-Me-A; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]purin-6-amine; 2'-Methyl-A; Adenosine, 2'-C-methyl-; 2'-C-Methyl-adenosine; 2'-C-Methyl-9-β-D-ribofuranosyladenine
EINECS	Contact for details

Quality Control

Our 2'-C-Methyladenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our quality commitment supports applications requiring high-purity reference standards and GMP-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.