Description

Boc-Gln-Onp is a protected amino acid derivative, specifically N-α-(tert-Butoxycarbonyl)-L-glutamine p-nitrophenyl ester. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), where it facilitates the controlled and efficient incorporation of glutamine residues. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, APIs, and biochemical probes. The product is supplied under the identifier CAS NO 15387-45-8, ensuring precise material traceability.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester, it is a key reagent for the efficient coupling of Boc-protected glutamine in automated and manual peptide assembly.
• Pharmaceutical Intermediate: Used in the research and development of therapeutic peptides and active pharmaceutical ingredients (APIs) containing glutamine.
• Bioconjugation: Serves as a reactive handle for attaching glutamine-containing peptide sequences to other molecules, surfaces, or carriers.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, protein engineering, and the synthesis of custom peptide antigens or standards.
• Combinatorial Chemistry: A valuable building block for generating diverse peptide libraries for drug discovery and screening applications.

Basic Information

Product Name	Boc-Gln-Onp
CAS No.	15387-45-8
Molecular Formula	C₁₆H₂₁N₃O₇
Molecular Weight	367.35 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-L-glutamine p-nitrophenyl ester; Boc-L-glutamine p-nitrophenyl ester; Boc-Gln-ONp; (S)-2-((tert-Butoxycarbonyl)amino)-5-amino-5-oxopentanoic acid 4-nitrophenyl ester; N-Boc-L-glutamine 4-nitrophenyl ester; tert-Butyloxycarbonyl-L-glutamine p-nitrophenyl ester; Boc-Gln-ONp CAS 15387-45-8
EINECS	Contact for details

Quality Control

Our Boc-Gln-Onp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and loss on drying. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Solubility	Soluble in DMF, DMSO; sparingly soluble in organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.