Description

Phenolphthalein Glucuronic Acid CAS NO 15265-26-6 is a specialized biochemical conjugate formed from phenolphthalein and glucuronic acid. This compound is a critical reagent and reference standard in biochemical research and pharmaceutical development, particularly for studying glucuronidation, a major metabolic pathway. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors who require high-purity substrates for enzyme assays and metabolic studies.

Application

• Enzyme Substrate for β-Glucuronidase Assays: Primary use as a chromogenic substrate to measure β-glucuronidase activity in research and diagnostic kits.
• Metabolic Pathway Research: Used as a model compound to study the kinetics and mechanisms of glucuronidation by UDP-glucuronosyltransferase (UGT) enzymes.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for method development and validation in drug metabolism and pharmacokinetics (DMPK) studies.
• Biochemical Reagent: Employed in the development of colorimetric and fluorometric assays for detecting enzyme activity in cell lysates and biological fluids.
• Toxicology and Environmental Testing: Applied in assays designed to monitor glucuronidation activity as a biomarker in toxicological studies.
• Diagnostic Manufacturing: A key raw material in the production of specific diagnostic test strips and reagents for clinical laboratories.

Basic Information

Product Name	Phenolphthalein Glucuronic Acid
CAS No.	15265-26-6
Molecular Formula	C26H20O10
Molecular Weight	492.43 g/mol
Synonyms	Phenolphthalein Glucuronide; Phenolphthalein β-D-Glucuronide; Phenolphthalein Mono-β-D-Glucuronide; Phenolphthalein-β-D-Glucopyranosiduronic Acid; 8-[3-O-(β-D-Glucopyranosyluronic acid)-4-oxo-3H-xanthen-9-yl]benzoic Acid; PHL-G; PPG; PGR; β-Glucuronidase Substrate
EINECS	Contact for details

Quality Control

Our Phenolphthalein Glucuronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.