Description

2,4,6-Trimethyl-1,3-Benzenedicarbonitrile Oxide is a specialized aromatic nitrile oxide derivative, a key reactive intermediate in synthetic organic chemistry. Its primary value lies in its role as a versatile 1,3-dipole for [3+2] cycloaddition reactions, enabling the efficient construction of complex heterocyclic scaffolds. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to synthesize novel isoxazoline and isoxazole derivatives with potential biological activity.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing isoxazoline and isoxazole cores found in drug discovery and development programs.
• Agrochemical Synthesis: Used in the creation of novel active ingredients, particularly those with herbicidal or insecticidal properties based on the isoxazoline pharmacophore.
• Click Chemistry: Serves as a potent dipolarophile in copper-free or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions for bioconjugation and materials science.
• Polymer & Material Science: Employed in the synthesis of functionalized polymers and advanced materials through cycloaddition reactions to introduce specific chemical functionalities.
• Ligand & Catalyst Development: Acts as a precursor for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis and the exploration of new reaction pathways.

Basic Information

Product Name	2,4,6-Trimethyl-1,3-Benzenedicarbonitrile Oxide
CAS No.	15138-43-9
Molecular Formula	C11H10N2O
Molecular Weight	186.21 g/mol
Synonyms	1,3-Dicyano-2,4,6-trimethylbenzene Oxide; 2,4,6-Trimethylisophthalonitrile Oxide; 2,4,6-Trimethyl-1,3-phenylenedicarbonitrile Oxide; Mesitylene-1,3-dicarbonitrile Oxide; 1,3-Bis(cyanomethyl)-2,4,6-trimethylbenzene Oxide (common misnomer); TMDNO (abbreviation); Mesitylenedinitrile Oxide
EINECS	Contact for details

Quality Control

Our 2,4,6-Trimethyl-1,3-Benzenedicarbonitrile Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is typically light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents and reducing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.