Description

3-Hydroxypyrrolidin-2-One is a versatile heterocyclic building block and chiral intermediate of significant importance in advanced organic synthesis. Its pyrrolidinone core, functionalized with a hydroxyl group, makes it a valuable precursor for constructing complex molecules with specific stereochemistry. This compound is particularly sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), natural product analogs, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, including potential treatments for neurological disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its structure can contribute to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Natural Product and Alkaloid Synthesis: A building block for the laboratory synthesis of complex natural products containing pyrrolidine or pyrrolidinone motifs.
• Polymer Science Research: Investigated as a monomer or modifying agent for creating specialty polymers with unique properties.
• Bioconjugation and Probe Chemistry: The hydroxyl and carbonyl groups provide handles for chemical modification in bioconjugation applications.

Basic Information

Product Name	3-Hydroxypyrrolidin-2-One
CAS No.	15116-68-4
Molecular Formula	C₄H₇NO₂
Molecular Weight	101.10 g/mol
Synonyms	3-Hydroxy-2-pyrrolidinone; 3-Hydroxypyrrolidin-2-one; 2-Pyrrolidinone, 3-hydroxy-; 3-Hydroxy-tetrahydro-2H-pyrrol-2-one; 3-Hydroxy-2-pyrrolidone; 3-Hydroxyazolidin-2-one; (S)-3-Hydroxypyrrolidin-2-one (for enantiopure form); (R)-3-Hydroxypyrrolidin-2-one (for enantiopure form)
EINECS	Contact for details

Quality Control

Our 3-Hydroxypyrrolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets high-purity standards suitable for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Optical Purity (Chiral HPLC)	Available for specific enantiomers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.