Description

tert-Butyl 3-Phenyl-L-Alaninate Hydrochloride is a protected amino acid derivative, specifically the hydrochloride salt of the tert-butyl ester of L-phenylalanine. This compound is a crucial chiral building block in the synthesis of complex peptides and pharmaceutical intermediates, offering enhanced stability and solubility for specific reaction sequences. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing active pharmaceutical ingredients (APIs) and novel therapeutic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based drugs and other bioactive molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) where the tert-butyl ester serves as a protecting group for the carboxylic acid functionality.
• Proteomics Research: Employed in the design and study of peptide analogs, enzyme substrates, and inhibitors for biochemical research.
• Asymmetric Synthesis: Serves as a source of the L-phenylalanine moiety in stereoselective chemical transformations.
• Reference Standard: Used as a high-purity standard in analytical laboratories for method development and quality control.

Basic Information

Product Name	tert-Butyl 3-Phenyl-L-Alaninate Hydrochloride
CAS No.	15100-75-1
Molecular Formula	C₁₃H₂₀ClNO₂
Molecular Weight	257.76 g/mol
Synonyms	L-Phenylalanine, tert-butyl ester, hydrochloride; (S)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropanoic acid hydrochloride; Boc-Phe-OtBu·HCl; tert-Butyl (S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate hydrochloride; N-Boc-L-phenylalanine tert-butyl ester hydrochloride; 3-Phenyl-L-alanine tert-butyl ester hydrochloride; (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate hydrochloride
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Phenyl-L-Alaninate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98.5%), and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation	[α]²⁰D: -15° to -20° (c=1 in Methanol)
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.