Description

Z-Aib-Oh is a high-purity, non-proteinogenic amino acid derivative featuring a Cα-tetrasubstituted structure, widely recognized for its role in peptide backbone modification. This compound is valued for its ability to induce specific conformational constraints in peptide chains, enhancing metabolic stability and biological activity. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel peptide-based therapeutics and diagnostic agents.

Application

• Peptide Synthesis: As a critical building block for incorporating the 2-aminoisobutyric acid (Aib) residue into custom peptides to study structure-activity relationships.
• Pharmaceutical Research: For the design and synthesis of peptidomimetics with enhanced stability against enzymatic degradation for drug discovery programs.
• Bioconjugation: Utilized in the preparation of chemically modified peptides for conjugation with other molecules, such as dyes or polymers.
• Material Science: Serves as a precursor for creating novel bio-inspired materials and foldamers with specific structural properties.
• Academic & Industrial R&D: A fundamental reagent in laboratories focusing on organic chemistry, medicinal chemistry, and peptide science.

Basic Information

Product Name	Z-Aib-Oh
CAS No.	15030-72-5
Molecular Formula	C12H15NO4
Molecular Weight	237.25 g/mol
Synonyms	N-Cbz-2-aminoisobutyric acid; N-Carbobenzoxy-2-aminoisobutyric acid; (2S)-2-[[(Benzyloxy)carbonyl]amino]-2-methylpropanoic acid; Z-Aib-OH; Cbz-Aib-OH; Nα-Cbz-α-aminoisobutyric acid; N-Benzyloxycarbonyl-2-aminoisobutyric acid; 2-[[(Phenylmethoxy)carbonyl]amino]-2-methylpropanoic acid
EINECS	Contact for details

Quality Control

Our Z-Aib-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific research or cGMP starting material requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.