Description

n-Cbz-L-Histidine is a protected derivative of the essential amino acid L-Histidine, where the carboxybenzyl (Cbz) group safeguards the amine functionality. This compound is a critical building block in peptide synthesis, enabling the controlled elongation of peptide chains while preventing unwanted side reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for developing novel therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the stepwise construction of custom peptides in drug discovery and development.
• Solution-Phase Peptide Synthesis: Used in classical methods for producing larger quantities of specific peptide sequences.
• Pharmaceutical Intermediates: Serves as a key intermediate in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Facilitates the site-specific labeling or modification of proteins and other biomolecules for diagnostic or research purposes.
• Biochemical Research: Employed in studying enzyme-substrate interactions, receptor binding, and other histidine-dependent biological processes.
• Protecting Group Chemistry: Acts as a model compound for studying the introduction and removal (e.g., hydrogenolysis) of the Cbz protecting group.

Basic Information

Product Name	n-Cbz-L-Histidine
CAS No.	14997-58-1
Molecular Formula	C14H17N3O4
Molecular Weight	291.30 g/mol
Synonyms	Nα-Carbobenzoxy-L-histidine; N-Carboxybenzyl-L-histidine; Z-L-Histidine; CBZ-L-Histidine; (S)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoic acid; L-Histidine, N-[(phenylmethoxy)carbonyl]-; NSC 334884; Boc-His(Z)-OH (common misnomer, correct is Cbz)
EINECS	Contact for details

Quality Control

Our n-Cbz-L-Histidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-10.0° to -14.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0% L-isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.