Description

Vasopressin, n-(n-Gly-Gly)-8-Lys- (CAS NO 14943-47-6) is a synthetic analogue of the endogenous neurohypophyseal hormone vasopressin, modified with a glycyl-glycyl-lysine extension. This modification is critical for enhancing its stability and altering its receptor binding profile, making it a valuable tool for advanced biochemical and pharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers investigating peptide hormone signaling, renal physiology, and cardiovascular regulation.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies of vasopressin receptor (V1a, V1b, V2) subtypes, signal transduction pathways, and structure-activity relationships (SAR).
• Biochemical Assay Development: Serves as a key component in the development and validation of high-throughput screening (HTS) assays, ELISA kits, and radioimmunoassays (RIA) for vasopressin-related studies.
• Academic & Clinical Research: Employed in fundamental research exploring the role of vasopressin in water-electrolyte balance, blood pressure regulation, stress response, and social behavior.
• Peptide Chemistry & Drug Discovery: Acts as a sophisticated intermediate or model compound for developing novel peptide-based therapeutics with improved metabolic stability and pharmacokinetic properties.
• Diagnostic Manufacturing: Used in the production of calibrators and controls for in-vitro diagnostic (IVD) devices measuring vasopressin levels in clinical samples.

Basic Information

Product Name	Vasopressin, n-(n-Gly-Gly)-8-Lys-
CAS No.	14943-47-6
Molecular Formula	C52H78N16O15S2
Molecular Weight	1199.4 g/mol
Synonyms	[8-Lysine, Glycyl-glycyl]-vasopressin; [Gly-Gly-Lys8]-Vasopressin; Vasopressin, [Gly-Gly-Lys8]-; N-(N-Glycyl-glycyl)-8-L-lysine-vasopressin; 1-(3-Mercaptopropanoic acid)-2-(O-methyl-L-tyrosine)-8-L-lysine-glycyl-glycine vasopressin; AVP analogue; Arginine vasopressin Gly-Gly-Lys8 derivative
EINECS	Contact for details

Quality Control

Our Vasopressin, n-(n-Gly-Gly)-8-Lys- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) detailing purity, assay, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.