Description

Proline, 4-Ethyl-1-Methyl-, L-cis- (8Ci) is a specialized, non-proteinogenic proline derivative characterized by its unique ethyl and methyl substitutions on the pyrrolidine ring. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a key chiral building block for the synthesis of complex bioactive molecules. Its constrained, bicyclic-like structure makes it valuable for medicinal chemists and R&D professionals in the pharmaceutical and biotechnology sectors who are designing novel peptide-based therapeutics, enzyme inhibitors, and other high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel drug candidates, particularly in protease inhibitor and peptide mimetic research.
• Peptide Chemistry: Used to introduce conformational constraints into synthetic peptides, enhancing their metabolic stability and target selectivity.
• Biochemical Research: Serves as a tool compound in enzymology studies to investigate substrate specificity and enzyme mechanisms.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce stereoselectivity.
• Agrochemical Research: Potential building block for the synthesis of advanced, biologically active compounds in crop protection.
• Material Science: Exploration into functionalized polymers and advanced materials where its rigid structure can impart specific properties.

Basic Information

Product Name	Proline, 4-Ethyl-1-Methyl-, L-cis- (8Ci)
CAS No.	14811-15-5
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	L-cis-4-Ethyl-1-methylproline; (2S,4S)-4-Ethyl-1-methylpyrrolidine-2-carboxylic acid; 1-Methyl-4-ethyl-L-proline; cis-4-Ethyl-1-methyl-L-proline; 4-Ethyl-1-methylproline; 14811-15-5; L-Proline, 4-ethyl-1-methyl-, cis-
EINECS	Contact for details

Quality Control

Our production of Proline, 4-Ethyl-1-Methyl-, L-cis- (8Ci) adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and specific test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). For long-term storage, consider keeping the material under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.