Description

H-Asp(Leu-Oh)-Oh is a protected dipeptide derivative, specifically an aspartic acid residue linked to a leucine derivative. This compound is a crucial building block in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure and sequence. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, drug discovery, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediates: Serves as a key synthetic precursor in the development of peptide-based active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for constructing specific peptide sequences.
• Biochemical Research: Employed as a standard or reagent in studies of enzyme-substrate interactions, protein folding, and metabolic pathways.
• Drug Discovery: Acts as a scaffold or intermediate in medicinal chemistry programs targeting various diseases.
• Protecting Group Chemistry: Demonstrates the application of specific protecting groups (like -OtBu for the side chain) in multi-step organic syntheses.

Basic Information

Product Name	H-Asp(Leu-Oh)-Oh
CAS No.	14650-26-1
Molecular Formula	C14H26N2O5
Molecular Weight	302.37 g/mol
Synonyms	H-Asp(OtBu)-Leu-OH; L-Aspartic acid, 4-(1,1-dimethylethyl) ester, N-L-leucyl-; Asp(OtBu)-Leu; N-(tert-Butoxycarbonyl)-L-aspartyl-L-leucine; Boc-Asp(OtBu)-Leu-OH (related protected form); Aspartyl-leucine derivative; (S)-2-((S)-4-(tert-Butoxy)-4-oxobutanamido)-4-methylpentanoic acid
EINECS	Contact for details

Quality Control

Our H-Asp(Leu-Oh)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Specific Rotation	-20° to -25° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.