Description

D-3-Trifluoromethylphenylalanine is a non-natural, fluorinated derivative of the amino acid phenylalanine, characterized by a trifluoromethyl group at the meta position of the phenyl ring. This structural modification imparts unique electronic and steric properties, making it a valuable chiral building block for advanced synthesis. It is primarily utilized in pharmaceutical research and development, particularly for creating novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics. The compound's high optical purity and defined stereochemistry are critical for applications demanding precise molecular interactions.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel drug candidates, especially protease inhibitors and other targeted therapies.
• Peptide Modification: Used to incorporate fluorinated aromatic side chains into peptides to enhance metabolic stability, lipophilicity, and binding affinity.
• Agrochemical Research: Serves as a building block for developing new fluorinated pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science: Employed in the synthesis of specialty polymers and advanced materials where fluorine atoms confer specific chemical resistance or surface properties.
• Biochemical Tool: Utilized in enzymatic and metabolic studies to investigate substrate specificity and enzyme mechanisms due to its fluorinated structure.
• Asymmetric Synthesis: Acts as a versatile precursor or auxiliary in catalytic asymmetric reactions to construct complex chiral molecules.

Basic Information

Product Name	D-3-Trifluoromethylphenylalanine
CAS No.	14464-67-6
Molecular Formula	C10H10F3NO2
Molecular Weight	233.19 g/mol
Synonyms	(R)-3-(Trifluoromethyl)phenylalanine; D-3-(Trifluoromethyl)phenylalanine; (R)-2-Amino-3-[3-(trifluoromethyl)phenyl]propanoic acid; D-α-Amino-3-(trifluoromethyl)hydrocinnamic acid; (R)-3-Trifluoromethyl-D-phenylalanine; D-m-Trifluoromethylphenylalanine; (R)-m-Trifluoromethylphenylalanine; D-3-CF3-Phe
EINECS	Contact for details

Quality Control

Our D-3-Trifluoromethylphenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and enantiomeric excess is provided with every shipment. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.