Description

Cob(Ii)Alamin CAS NO 14463-33-3 is a reduced form of vitamin B12, specifically a cobalt(I) corrin complex, which serves as a key intermediate in biological methylation and synthesis processes. This compound is critical for research and development in biochemistry and pharmaceutical manufacturing due to its potent nucleophilic and catalytic properties. It is primarily utilized by researchers in life sciences, developers of enzymatic processes, and manufacturers of high-purity pharmaceutical intermediates and reference standards.

Application

• Biochemical Research: Essential as a cofactor and intermediate in studies of methionine synthase, methylmalonyl-CoA mutase, and other B12-dependent enzymatic pathways.
• Pharmaceutical Synthesis: Used as a key starting material or catalyst in the synthesis of complex vitamin B12 analogs and other cobalt-containing pharmaceuticals.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical and nutritional supplement testing.
• Enzymatic Process Development: Employed in the development and optimization of industrial biocatalysis for chiral synthesis and green chemistry applications.
• Nutritional Science: Investigated for its role in cellular metabolism and as a precursor in advanced nutritional formulations.

Basic Information

Product Name	Cob(Ii)Alamin
CAS No.	14463-33-3
Molecular Formula	C₆₂H₈₈CoN₁₃O₁₄P
Molecular Weight	1348.37 g/mol
Synonyms	Cob(I)alamin; Vitamin B12a (reduced form); B12r; Supernucleophilic B12; Cobalt(I)alamin; Co(I)cobalamin; Co(I) vitamin B12; Reduced Vitamin B12
EINECS	Contact for details

Quality Control

Our Cob(Ii)Alamin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via UV-Vis and IR spectroscopy, to ensure it meets rigorous standards for research and development use. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being strictly light-sensitive and easily oxidized, this material must be stored under an inert atmosphere (e.g., argon or nitrogen) at recommended temperatures of -20°C or below for long-term stability. The container should be kept in a cool, dry place and allowed to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Dark red to brown crystalline solid or powder
Identification (UV-Vis)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Contact for details
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.