Description

Z-Thr(Tbu)-Otbu CAS NO 14437-51-5 is a protected derivative of the amino acid threonine, specifically designed for use in peptide synthesis. This compound is critical for researchers and manufacturers who require high-purity, chemically stable building blocks to construct complex peptides without unwanted side reactions. It is an essential intermediate for pharmaceutical R&D, particularly in the development of therapeutic peptides, APIs, and novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the sequential assembly of peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for constructing peptide fragments.
• Pharmaceutical Intermediate: Serves as a critical raw material in the synthesis of Active Pharmaceutical Ingredients (APIs) for therapeutic peptides.
• Bioconjugation & Labeling: Provides a reactive handle for attaching labels, tags, or other molecules to peptides.
• Research & Development: Essential for academic and industrial research in medicinal chemistry, biochemistry, and proteomics.
• Custom Peptide Production: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Product Name	Z-Thr(Tbu)-Otbu
CAS No.	14437-51-5
Molecular Formula	C19H29NO6
Molecular Weight	367.44 g/mol
Synonyms	N-Carbobenzyloxy-O-tert-butyl-L-threonine tert-Butyl Ester; Z-O-tert-Butyl-L-threonine tert-Butyl Ester; Nα-Z-O-t-Butyl-L-threonine t-Butyl Ester; (2S,3R)-2-[[(Benzyloxy)carbonyl]amino]-3-[(2-methylpropan-2-yl)oxy]butanoic acid tert-butyl ester; Boc-Thr(tBu)-OtBu (common abbreviation context); Z-L-Thr(Tbu)-OtBu; Cbz-Thr(tBu)-OtBu; N-Cbz-O-tert-butylthreonine tert-butyl ester
EINECS	Contact for details

Quality Control

Our Z-Thr(Tbu)-Otbu is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is supplied with each batch to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.