Description

n-Butadecanoyl-D-Valine is a high-purity chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its value lies in its role as a protected D-valine derivative, where the n-butadecanoyl (myristoyl) group provides lipophilicity and can influence the pharmacokinetic properties of the final molecule. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules where stereochemical control is critical. Its application extends to materials science for creating specialized chiral surfaces or catalysts.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide drugs, protease inhibitors, and other active pharmaceutical ingredients (APIs) requiring the D-valine configuration.
• Bioconjugation & Prodrug Development: Used to introduce a lipophilic fatty acid chain (myristoyl) onto peptides or drug molecules to enhance cell membrane permeability or create prodrugs.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly those involving amino acid metabolism or chiral recognition.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective chemical reactions to induce desired chirality in complex molecules.
• Material Science: Potential use in the synthesis of chiral stationary phases for chromatography or in the fabrication of chiral molecular imprinted polymers (MIPs).

Basic Information

Product Name	n-Butadecanoyl-D-Valine
CAS No.	14379-31-8
Molecular Formula	C19H37NO3
Molecular Weight	327.51 g/mol
Synonyms	D-Valine, N-(1-oxotetradecyl)-; Myristoyl-D-valine; N-Myristoyl-D-valine; Tetradecanoyl-D-valine; (R)-2-(Tetradecanamido)-3-methylbutanoic acid; N-Tetradecanoyl-D-valine; (R)-2-(Myristoylamino)-3-methylbutanoic acid; D-Valine myristamide acid derivative
EINECS	Contact for details

Quality Control

Our n-Butadecanoyl-D-Valine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.