Description

17β-Estradiol 17-(2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester) is a key synthetic derivative of the primary female sex hormone, estradiol, designed for advanced research and development applications. This compound is critical for scientists requiring a protected and stable glucuronide conjugate for metabolic, pharmacokinetic, and analytical studies. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and academic institutions focused on endocrinology, drug metabolism, and biomarker analysis.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for the quantification and qualification of estradiol metabolites in complex biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Research: Used in studies investigating Phase II conjugation pathways, specifically glucuronidation, to understand drug and hormone clearance mechanisms.
• Biomarker Development: Essential for developing and validating sensitive LC-MS/MS or HPLC assays to detect steroid hormone conjugates in clinical or environmental samples.
• Enzymology Studies: Employed as a substrate for studying the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes.
• Synthetic Intermediate: Acts as a protected precursor in the chemical synthesis of other estradiol conjugates or for deprotection to obtain the free glucuronide.
• Endocrine Disruptor Research: Applied in environmental and toxicological studies to trace the fate and biotransformation of estrogenic compounds.

Basic Information

Item	Details
Product Name	17β-Estradiol 17-(2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester)
CAS No.	14364-66-0
Molecular Formula	C₃₄H₄₂O₁₄
Molecular Weight	674.70 g/mol
Synonyms	Estradiol 17-(Triacetylglucuronide) Methyl Ester; E2-17G-TriAc-Me; 17β-Estradiol 17-(2,3,4-Tri-O-acetyl-β-D-glucopyranosiduronic Acid) Methyl Ester; Estradiol 17-Glucuronide Triacetate Methyl Ester; 17β-Estradiol 17-β-D-Glucuronide Triacetate Methyl Ester; Methyl (2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-[(2R,3S)-3-[(8R,9S,13S,14S,17S)-13-methyl-17-[(1R)-1,2,2-trimethylcyclopentyl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxyoxolan-2-yl]oxyoxane-2-carboxylate
EINECS	Contact for details

Quality Control

Our 17β-Estradiol 17-(2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) detailing all specifications and results is provided to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.