Description

H-Gln-Onb HBr is a protected glutamine derivative, specifically N-(9-Fluorenylmethoxycarbonyloxy)succinimide-protected glutamine hydrobromide. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), offering a strategic solution for the controlled incorporation of glutamine residues while preventing side reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptide hormones, and therapeutic agents. The product is supplied as a high-purity intermediate to ensure optimal coupling efficiency and final peptide integrity.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated or manual synthesis of complex peptide sequences.
• Pharmaceutical Research: For the development and production of peptide-based drugs, vaccines, and diagnostic agents.
• Bioconjugation: Used in the site-specific modification of proteins or other biomolecules by introducing glutamine handles.
• Combinatorial Chemistry: Serves as a building block in libraries for high-throughput screening of bioactive peptides.
• Academic Research: Fundamental studies in biochemistry, molecular biology, and medicinal chemistry involving peptide structure-activity relationships.
• Process Development: Scaling up the synthesis of therapeutic peptides under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	H-Gln-Onb HBr
CAS No.	14349-18-9
Molecular Formula	C₂₀H₂₀BrN₃O₆
Molecular Weight	478.30 g/mol
Synonyms	Fmoc-Gln-ONb HBr; Nα-Fmoc-L-glutamine 4-nitrobenzyl ester hydrobromide; Fmoc-L-glutamine-γ-4-nitrobenzyl ester HBr; (9H-Fluoren-9-yl)methyl N-[(2S)-5-[(4-nitrophenyl)methoxy]-4-oxo-5-oxopentyl]carbamate hydrobromide; Fmoc-Gln(ONb)-OH·HBr; Fmoc-Glutamine(ONb)-OH hydrobromide; Protected Glutamine derivative; SPPS Glutamine building block
EINECS	Contact for details

Quality Control

Our H-Gln-Onb HBr is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and elemental analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research and pharmaceutical-grade standards. Specifications are designed to meet the rigorous demands of modern peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and performance. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.