Description

4-Epi-Demeclocycline is a tetracycline-class antibiotic derivative, primarily utilized as a critical reference standard and intermediate in pharmaceutical research and development. Its precise chemical structure is essential for analytical method development, quality control, and the synthesis of novel therapeutic agents. This high-purity compound is vital for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors who require reliable materials for method validation and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity testing of demeclocycline and related tetracycline antibiotics in compliance with pharmacopeial methods (e.g., USP, EP).
• Analytical Research: Serves as a critical impurity marker and calibrant in High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), and other analytical techniques.
• Biochemical Research: Employed in studies investigating the structure-activity relationships, metabolism, and resistance mechanisms of tetracycline antibiotics.
• Pharmaceutical Intermediate: Acts as a key synthetic building block in the research-scale preparation of specialized antibiotic derivatives and novel chemical entities.
• Quality Control Laboratories: Essential for in-house method development and validation within API (Active Pharmaceutical Ingredient) manufacturing facilities to ensure product purity and regulatory compliance.

Basic Information

Product Name	4-Epi-Demeclocycline
CAS No.	14206-59-8
Molecular Formula	C21H21ClN2O8
Molecular Weight	464.85 g/mol
Synonyms	4-Epidemeclocycline; Demeclocycline, 4-epi-; 4-Epi-Demeclocycline Hydrochloride (salt form); 6-Demethyl-6-deoxytetracycline, 4-epimer; 4-Epideclomycin; NSC 113112; 4-Epi-DMC; 4-Epianhydrodemeclocycline (related derivative)
EINECS	Contact for details

Quality Control

Our 4-Epi-Demeclocycline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical reference materials and research chemicals. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.