Description

Trimipramine n-Oxide is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant trimipramine. This compound is essential for research and development in neuropharmacology, particularly in studies related to drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of high-purity active pharmaceutical ingredients (APIs) and their metabolites.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the qualitative and quantitative analysis of trimipramine and its metabolites in biological matrices.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic pathways, bioavailability, and excretion profiles of trimipramine.
• Analytical Method Development: Used as a standard in developing and validating HPLC, LC-MS, and GC-MS methods for pharmacokinetic and bioequivalence studies.
• Impurity Profiling: Employed in the identification and quantification of oxidative degradation products in trimipramine API and finished dosage forms.
• Pharmacological Studies: A tool for researching the activity and potential effects of trimipramine metabolites in central nervous system (CNS) target engagement assays.
• Chemical Synthesis: Acts as a specialized intermediate or starting material for the synthesis of novel chemical entities or labeled analogs in medicinal chemistry.

Basic Information

Product Name	Trimipramine n-Oxide
CAS No.	14171-70-1
Molecular Formula	C20H26N2O
Molecular Weight	310.44 g/mol
Synonyms	5-[3-(Dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenzo[b,f]azepine N-oxide; Trimipramine N-Oxide; Trimipramine Oxide; N-Desmethyltrimipramine N-Oxide; 14171-70-1; Trimipramine Impurity; Trimipramine Metabolite
EINECS	Contact for details

Quality Control

Our Trimipramine n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances and residual solvents, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.