Description

Clomipramine n-Oxide is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant clomipramine. Its significance lies in its role in pharmacological research, metabolism studies, and the development of analytical reference standards. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on neuropharmacology, drug metabolism and pharmacokinetics (DMPK), and quality control laboratories.

Application

• Pharmaceutical Intermediate: Critical synthesis component for specialized neuropharmacological agents and related chemical entities.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods (LC-MS, HPLC) for quantifying clomipramine and its metabolites in biological matrices.
• Pharmacological Research: Employed in studies investigating the metabolism, pharmacokinetics, and activity profile of tricyclic antidepressants.
• Quality Control & Assurance: Serves as a high-purity impurity standard for the analytical testing of clomipramine active pharmaceutical ingredient (API) and finished drug products.
• Biochemical Tool: Utilized in enzymatic and metabolic pathway studies within neuroscience and pharmacology research.
• Regulatory Compliance: Supports regulatory filings by providing characterized material for stability studies and method validation.

Basic Information

Product Name	Clomipramine n-Oxide
CAS No.	14171-67-6
Molecular Formula	C19H23ClN2O
Molecular Weight	330.85 g/mol
Synonyms	3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine N-Oxide; Clomipramine N-Oxide; Clomipramine Oxide; Clomipramine Metabolite; N-Desmethylclomipramine N-Oxide (related); Anafranil Metabolite; 5-[3-(Dimethylamino)propyl]-10,11-dihydro-3-chloro-5H-dibenz[b,f]azepine N-Oxide
EINECS	Contact for details

Quality Control

Our Clomipramine n-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards for research and development use. Certificates of Analysis (COA) detailing specific results for assay, impurities, and identification are provided with every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.